![]() The two could be seen attending different awards ceremonies and functions together. This relationship looked flawless but was not from the inner core. Previously, Lana was married to Thea Bloom in 1993. Lana Wachowski is married to an actress named Karin Winslow. Winslow is a board member of the Chicago House and Social Service Agency. Lana Wachowski is married to an actress Karin Winslow. Even though being famous in showbiz, her love life gains the most attention, which is right ahead of this article. In Chicago, Illinois, Lana was born on June 21, 1965, to Lynne (née Luckinbill) mother and father, Ron Wachowski, a nurse, painter, and businessman of Polish descent. She first debuted directing in 1996 with Bound and achieved fame with the second film, The Matrix (1999), which gave a hit box office success. Uncovering the extent of heterogeneity within the postnatal pituitary stem cell compartment and cross-talk between the WNT and Hippo pathways is key to understanding their potential for regenerative therapies to treat prevalent pituitary disorders.Inside Lana Wachowski's Married Life: The Filmmaker is Married to a second wife!įormerly known as Larry Wachowski, Lana Wachowski is a well-known film and television director, writer, and producer. Secondly, levels of interplay between Hippo and WNT signalling will be assessed in these cells, utilising proximal-protein interaction assays and analyses of mutant murine lines. Two branches of novel investigations are necessary to elucidate the importance and function of different subgroups within this heterogenous stem cell population.įirstly, bioinformatic approaches will be utilised to identify specific subpopulation markers for assessment of stem cell potential and function in vitro and in vivo. In addition, WNT ligands have been shown to be secreted from a subgroup of the stem cells, promoting the proliferation of fate-determined progenitor populations to maintain the postnatal gland. Furthermore, recent data from our lab has implicated Hippo pathway effector proteins YAP/TAZ as crucial for maintaining homeostasis within the stem cell population, with dysregulation causing tumourigenesis. This stem cell population is inherently heterogenous, with undefined subgroups promoting self-renewal, whilst others commit to hormone-specific lineages or remain quiescent. Subsequently, this gland has to remain plastic to respond to ever-changing demands for hormones throughout life, and does so, in part, through changes in the tissue-specific stem cell population. The pituitary gland controls processes such as growth, pregnancy, response to stress and metabolism. PhD Programme – Years 2 to 4 – Doctoral Studiesįor my PhD project I have chosen to join the lab of Dr Cynthia Andoniadou to investigate the stem cell population of the pituitary. As well as learning some bioinformatics, I used mouse models and in vitro staining techniques to learn about these novel sub-populations (see image).įor my final rotation I joined the lab of Dr Charalambous to research the transcriptional regulation of ZAC1 on imprinted genes using CUT&RUN, a new epigenomic profiling strategy. PhD Programme – Year 1 – MRes and Project Rotationsįor my first rotation I worked with Dr Guermonprez to optimise the differentiation of iPSCs into hematopoietic stem cells and dendritic cells.ĭuring my second rotation with Dr Andoniadou I learnt how to analyse single cell RNA sequencing data using bioinformatics and used this to investigate heterogeneity in the stem cell compartment of the pituitary gland. ![]() When I returned to Bath for my final year, I joined Professor Tosh’s lab where I was involved in the characterization of novel transcription factors associated with transdifferentiation events that occur in Barrett’s Oesophagus disease. ![]() During my degree, I undertook a placement year to research novel autophagy adaptor proteins in redox homeostasis under Professor Luo at the Peninsula Schools of Medicine and Dentistry. I completed my undergraduate degree in Molecular and Cellular Biology at the University of Bath. Academic and Work Experience Prior to Sept 2018 Programme Start
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |